Towards a microfluidic device for investigating neurally mediated cardiac wave dynamics

Myocardial infarcts are often associated with increased neural innervation surrounding the infarct scar. This nerve sprouting is risk of arrhythmias and sudden death. Despite decades study, fundamental questions remain open, including whether heterogeneous activity proarrhythmic number neurons needed to modulate dynamics at tissue level. Arrhythmogenic mechanisms in vivo poorly understood as key physiological parameters not experimentally accessible.